Seminars in Arthroplasty
Volume 18, Issue 3 , Pages 203-210 , September 2007

Osteonecrosis of the Femoral Head in Pediatric Cancer Patients

  • Michael D. Neel, MD

      Affiliations

    • Department of Surgery, St. Jude Children’s Research Hospital, Memphis, TN.
    • Corresponding Author InformationAddress reprint requests to Michael D. Neel, MD, Orthomemphis, P.C., 6286 Briarcrest Ave., Memphis, TN 38120.
    • ,
  • Evguenia J. Karimova, MD

      Affiliations

    • Department of Radiological Sciences, St. Jude Children’s Research Hospital, Memphis, TN.

References 

  1. Ojala AE, Paakko E, Lanning FP, et al. Osteonecrosis during the treatment of childhood acute lymphoblastic leukemia: A prospective MRI study. Med Pediatr Oncol. 1999;32:11–17
  2. Niinimaki RA, Harila-Saari AH, Jartti AE, et al. High body mass index increases the risk for osteonecrosis in children with acute lymphoblastic leukemia. J Clin Oncol. 2007;25:1498–1504
  3. Sala A, Mattano LA, Barr RD. Osteonecrosis in children and adolescents with cancer: An adverse effect of systemic therapy. Eur J Cancer. 2006;43:683–689
  4. Relling MV, Yang W, Das S, et al. Pharmacogenetic risk factors for osteonecrosis of the hip among children with leukemia. J Clin Oncol. 2004;22:3930–3936
  5. Kaste SC, Shidler TJ, Tong X, et al. Bone mineral density and osteonecrosis in survivors of childhood allogeneic bone marrow transplantation. Bone Marrow Transplant. 2004;33:435–441
  6. Balduzzi A, Gooley T, Anasetti C, et al. Unrelated donor marrow transplantation in children. Blood. 1995;86:3247–3256
  7. Pui CH, Evans WE. Treatment of acute lymphoblastic leukemia. N Engl J Med. 2006;354:166–178
  8. Nachman JB. My aching bones: Skeletal complications of acute lymphoblastic leukemia. Pediatr Blood Cancer. 2006;46:1
  9. Gaughan DM, Mofenson LM, Hughes MD, et al. Osteonecrosis of the hip (Legg–Calve–Perthes disease) in human immunodeficiency virus-infected children. Pediatrics. 2002;109:E74
  10. Gupta D, Gaiha M, Siddaraju N, et al. Chronic myeloid leukemia presenting with avascular necrosis of femur head. J Assoc Physicians India. 2003;51:214–215
  11. Jonsson OG, Sartain P, Ducore JM, et al. Bone pain as an initial symptom of childhood acute lymphoblastic leukemia: Association with nearly normal hematologic indexes. J Pediatr. 1990;117:233–237
  12. Strauss AJ, Su JT, Dalton VM, et al. Bony morbidity in children treated for acute lymphoblastic leukemia. J Clin Oncol. 2001;19:3066–3072
  13. Karimova EJ, Rai SN, Howard SC, et al. Femoral head osteonecrosis in pediatric and young adult patients with leukemia or lymphoma. J Clin Oncol. 2007;25:1525–1531
  14. Arico M, Boccalatte MF, Silvestri D, et al. Osteonecrosis: An emerging complication of intensive chemotherapy for childhood acute lymphoblastic leukemia. Haematologica. 2003;88:747–753
  15. Mattano LA, Sather HN, Trigg ME, et al. Osteonecrosis as a complication of treating acute lymphoblastic leukemia in children: A report from the Children’s Cancer Group. J Clin Oncol. 2000;18:3262–3272
  16. Lackner H, Benesch M, Moser A, et al. Aseptic osteonecrosis in children and adolescents treated for hemato-oncologic diseases: A 13-year longitudinal observational study. J Pediatr Hematol Oncol. 2005;27:259–263
  17. Korholz D, Bruder M, Engelbrecht V, et al. Aseptic osteonecrosis in children with acute lymphoblastic leukemia. Pediatr Hematol Oncol. 1998;15:307–315
  18. Steinberg ME, Bands RE, Parry S, et al. Does lesion size affect the outcome in avascular necrosis?. Clin Orthop Relat Res. 1999;367:262–271
  19. Jergesen HE, Khan AS. The natural history of untreated asymptomatic hips in patients who have non-traumatic osteonecrosis. J Bone Joint Surg Am. 1997;79:359–363
  20. Cheng EY, Thongtrangan I, Laorr A, et al. Spontaneous resolution of osteonecrosis of the femoral head. J Bone Joint Surg Am. 2004;86A:2594–2599
  21. Mont MA, Carbone JJ, Fairbank AC. Core decompression versus nonoperative management for osteonecrosis of the hip. Clin Orthop Relat Res. 1996;324:169–178
  22. Mont MA, Ragland PS, Etienne G. Core decompression of the femoral head for osteonecrosis using percutaneous multiple small-diameter drilling. Clin Orthop Relat Res. 2004;429:131–138
  23. Castro FP, Barrack RL. Core decompression and conservative treatment for avascular necrosis of the femoral head: A meta-analysis. Am J Orthop. 2000;29:187–194
  24. Scully SP, Aaron RK, Urbaniak JR. Survival analysis of hips treated with core decompression or vascularized fibular grafting because of avascular necrosis. J Bone Joint Surg Am. 1998;80:1270–1275
  25. Gangji V, Toungouz M, Hauzeur JP. Stem cell therapy for osteonecrosis of the femoral head. Expert Opin Biol Ther. 2005;5:437–442

PII: S1045-4527(07)00041-7

doi: 10.1053/j.sart.2007.06.009

Seminars in Arthroplasty
Volume 18, Issue 3 , Pages 203-210 , September 2007

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