Seminars in Arthroplasty
Volume 18, Issue 3 , Pages 184-191, September 2007

Detecting Thrombophilia, Hypofibrinolysis and Reduced Nitric Oxide Production in Osteonecrosis

  • Charles J. Glueck, MD

      Affiliations

    • Cholesterol Center, Jewish Hospital, Cincinnati, OH.
    • Corresponding Author InformationAddress reprint requests to Charles J. Glueck, MD, Cholesterol Center, ABC Building, 3200 Burnet Avenue, Cincinnati, OH.
    • ,
  • Richard A. Freiberg, MD

      Affiliations

    • Cincinnati Veterans Administration Hospital, Cincinnati, OH.
    • ,
  • Ping Wang, PhD

      Affiliations

    • Cholesterol Center, Jewish Hospital, Cincinnati, OH.

Gene mutations leading to thrombophilia, hypofibrinolysis, and reduced nitric oxide production are risk factors for osteonecrosis. The importance of the diagnosis of thrombophilia–hypofibrinolysis in idiopathic osteonecrosis lies in the potential to stop the progression of osteonecrosis when enoxaparin is started at Ficat stages I or II before irreversible segmental collapse of the head of the femur.

Keywords: thrombophilia, hypofibrinolysis, osteonecrosis, reduced nitric oxide production

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 One or more of the authors (CJG) has received funding from the Jewish Hospital Medical Research Council. None of the authors has any conflicts of interest.The Jewish Hospital Institutional Review Board approved the human protocol for this investigation and that all investigations were conducted in conformity with ethical principles of research, and that informed consent was obtained.

PII: S1045-4527(07)00039-9

doi:10.1053/j.sart.2007.06.005

Seminars in Arthroplasty
Volume 18, Issue 3 , Pages 184-191, September 2007

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