Seminars in Arthroplasty
Volume 18, Issue 3 , Pages 175-179 , September 2007

Tracing the Genetic Origins of Osteonecrosis of the Femoral Head

  • Wei-Ming Chen, MD

      Affiliations

    • Department of Surgery and Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
    • Department of Orthopedics and Traumatology, Taipei Veterans General Hospital, Taipei, Taiwan.
    • ,
  • Yu-Fen Liu, PhD

      Affiliations

    • Institute of Genome Sciences and Genome Research Center, National Yang-Ming University, Taipei, Taiwan.
    • ,
  • Shih-Feng Tsai, MD, PhD

      Affiliations

    • Institute of Genome Sciences and Genome Research Center, National Yang-Ming University, Taipei, Taiwan.
    • Division of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli, Taiwan.
    • Institute of Molecular Medicine, National Tsing-Hua University, Hsinchu, Taiwan.
    • Corresponding Author InformationAddress reprint requests to Shih-Feng Tsai, MD, PhD, Division of Molecular and Genomic Medicine, National Health Research Institutes, 35 Keyan Road, Zhunan Town, Miaoli County 350, Taiwan.

References 

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  3. Jones LC, Hungerford DS. Osteonecrosis: Etiology, diagnosis, and treatment. Curr Opin Rheumatol. 2004;16:443–449
  4. Kenzora JE, Glimcher MJ. Accumulative cell stress: The multifactorial etiology of idiopathic osteonecrosis. Orthop Clin North Am. 1985;16:669–679
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  13. Asano T, Takahashi KA, Fujioka M, et al. ABCB1, C3435T, and G2677T/A polymorphism decreased the risk for steroid-induced osteonecrosis of the femoral head after kidney transplantation. Pharmacogenetics. 2003;13:675–682
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  15. Liu YF, Chen WM, Lin YF, et al. Type II collagen gene variants and inherited osteonecrosis of the femoral head. N Engl J Med. 2005;352:2294–2301
  16. Miyamoto Y, Matsuda T, Kitoh H, et al. A recurrent mutation in type II collagen gene causes Legg-Calve-Perthes disease in a Japanese family. Hum Genet. 2007;
  17. Kenet G, et al. The 1226G (N370S) Gaucher mutation among patients with Legg-Calve-Perthes disease. Blood Cells Mol Dis. 2003;31:72–74
  18. Rollot F, et al. Hemochromatosis and femoral head aseptic osteonecrosis: A nonfortuitous association?. J Rheumatol. 2005;32:376–378
  19. Lien YH, Lai LW. Bilateral femoral head and distal tibial osteonecrosis in a patient with Fabry disease. Am J Orthop. 2005;34:192–194
  20. Chen WM, Liu YF, Lin MW, et al. Autosomal dominant avascular necrosis of femoral head in two Taiwanese pedigrees and linkage to chromosome 12q13. Am J Hum Genet. 2004;75:310–317
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  24. Guttmacher AE, Collins FS. Welcome to the genomic era. N Engl J Med. 2003;349:996–998
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PII: S1045-4527(07)00037-5

doi: 10.1053/j.sart.2007.06.003

Seminars in Arthroplasty
Volume 18, Issue 3 , Pages 175-179 , September 2007

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